Cblb Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comCblb Polyclonal Antibody for Rat(Rattus norvegicus)

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Cblb (Gene name),

E3 ubiquitin-protein ligase CBL-B (Protein name ), CBLB_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cblb;

Protein name:

E3 ubiquitin-protein ligase CBL-B;

Alternative:

SH3-binding protein CBL-B;Casitas B-lineage lymphoma proto-oncogene b;Signal transduction protein CBL-B;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with SH3 domain-containing proteins LCK, CRK and SORBS1. Interacts with LCP2 and ZAP70. May interact with CBL. Interacts with SH3 domain-containing proteins VAV1, FYN, FGR, PLCG1, GRB2, CRKL, PIK3R1 and SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85, CD2AP and ARHGEF7, where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin.

Function:

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.

Subcellular Location:

Cytoplasm In mast cells, translocates to lipid raft upon FCER1 engagement.

Protein Attributes:

Sequence length:

938

Sequence:

50:

100:

150:

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250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

938:

AFEEVKRALE | IAQNNLEVAR | SILREFAFPP | PVSPRLNL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000039085

String:

Q8K4S7

UniGene:

Rn.21799

SMR:

Q8K4S7

KEGG:

rno:171136

Pfam:

PF02262

Uniprot:

Q8K4S7

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ELISA Kit for Rat E3 ubiquitin-protein ligase CBL-B

Cat.:

E2531h

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96T

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ELISA Kit for Rat E3 ubiquitin-protein ligase CBL-B

Cat.:

E2531m

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96T

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ELISA Kit for Rat E3 ubiquitin-protein ligase CBL-B

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E2531r

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96T

CLIA Kit for Rat E3 ubiquitin-protein ligase CBL-B

Cat.:

U2531m

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96T

CLIA Kit for Rat E3 ubiquitin-protein ligase CBL-B

Cat.:

U2531h

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MSDS:

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96T

CLIA Kit for Rat E3 ubiquitin-protein ligase CBL-B

Cat.:

U2531r

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96T

Polyclonal Antibody for Rat E3 ubiquitin-protein ligase CBL-B

Cat.:

P2531Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat E3 ubiquitin-protein ligase CBL-B

Cat.:

P2531Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat E3 ubiquitin-protein ligase CBL-B

Cat.:

P2531Rb-h

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40ug/0.2ml

Monoclonal Antibody for Rat E3 ubiquitin-protein ligase CBL-B

Protein for Rat E3 ubiquitin-protein ligase CBL-B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cblb is a major susceptibility gene for rat type 1 diabetes mellitus."
Yokoi N. , Komeda K. , Wang H.-Y. , Yano H. , Kitada K. , Saitoh Y. , Seino Y. , Yasuda K. , Serikawa T. , Seino S.
Nat. Genet.31:391-394(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DISEASE
tissue: Spleen.
2.

"Identification of cbl-b as a putative binding partner of SH3 domains of erythroid and non-erythroid alpha-spectrin (alpha-fodrin)."
Nicolas G. , Galand C. , Lecomte M.-C.
Submitted (1999-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 738-938
strain: Sprague-Dawley.
tissue: Kidney.
3.

"Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b."
Qu X. , Sada K. , Kyo S. , Maeno K. , Miah S.M. , Yamamura H.
Blood103:1779-1786(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
4.

"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
Hoffert J.D. , Pisitkun T. , Wang G. , Shen R.-F. , Knepper M.A.
Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-633;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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